Dr. Krishna Pada Bhabak

Profil

Derzeitige StellungProfessor W-2 und Äquivalente
FachgebietBioorganische und Biologische Chemie,Pharmazie
KeywordsStimuli-responsive prodrugs, Turn-on fluorogenic drug delivery, Organochalcogen-based anti-cancer agents, Scavengers of biological oxidants, Organic donors of hydrogen sulfide
Auszeichnungen

2013: INSPIRE Faculty Award by Department of Science and Technology (DST), India

2010: Best Thesis Award by Eli Lilly and Company Outstanding Thesis Award 2010 in Asia

Aktuelle Kontaktadresse

LandIndien
OrtGuwahati
Universität/InstitutionIndian Institute of Technology (IIT) Guwahati
Institut/AbteilungDepartment of Chemistry
Websitehttp://iitg.ac.in/kbhabak/Home.html

Gastgeber*innen während der Förderung

Prof. Dr. Christoph ArenzInstitut für Chemie, Humboldt-Universität zu Berlin, Berlin
Beginn der ersten Förderung01.09.2010

Programm(e)

2010Humboldt-Forschungsstipendien-Programm für Postdocs

Publikationen (Auswahl)

2025Pal, Nikita and Banerjee, Kaustav and Sarkar, Shilpi and Mandal, Tapas K and Bhabak, Krishna P: Cover Feature: Synthesis of Thiazolidinedione-and Triazole-Linked Organoselenocyanates and Evaluation of Anticancer Activities Against Breast Cancer with Mechanistic Investigations (Chem. Eur. J. 11/2025). In: Chemistry--A European Journal, 31, 2025, e202581102
2025Marandi, Shivani and Bhabak, Krishna P and Kumar, Sachin: Diallyl trisulfide inhibits in vitro replication of the Japanese encephalitis virus by modulating autophagy via mTOR-dependent pathway. In: Virology, 2025, 110575
2025Badirujjaman, Md and Thummer, Rajkumar P and Bhabak, Krishna P: Esterase-Responsive Self-Immolative Prodrugs for the Sustained Delivery of the Anticancer Drug 5-Fluorouracil with Turn-On Fluorescence. In: Chemistry--An Asian Journal, 20, 2025, e202400846
2025Banerjee, Kaustav and Sufian, Abu and Bhabak, Krishna P: Structurally Innovative Benzimidazole-fused Ionic Organoselenium Compounds: Prevalence of Se⋅⋅⋅ N/Se Chalcogen Bonds with the Selenocyanate Receptor. In: European Journal of Organic Chemistry, 28, 2025, e202401245
2025Pal, Nikita and Banerjee, Kaustav and Sarkar, Shilpi and Mandal, Tapas K and Bhabak, Krishna P: Synthesis of Thiazolidinedione-and Triazole-Linked Organoselenocyanates and Evaluation of Anticancer Activities Against Breast Cancer with Mechanistic Investigations. In: Chemistry--A European Journal, 31, 2025, e202403026
2025Sufian, Abu and Bhattacherjee, Debojit and Barman, Pallavi and Kesarwani, Rahul and Das, Samanaway and Bhabak, Krishna P: Synthetic organic polysulfanes as H 2 S donors and anticancer agents. In: Chemical Communications, 61, 2025, 4647--4661
2024Misra, Roopjyoti and Barman, Pallavi and Bhabak, Krishna P: Esterase-Responsive Fluorogenic Prodrugs of Aldose Reductase Inhibitor Epalrestat: An Innovative Strategy toward Enhanced Anticancer Activity. In: ACS Applied Bio Materials, 7, 2024, 6542--6553
2024Sufian, Abu and Parihar, Nidhi and Badirujjaman, Md and Barman, Pallavi and Kesarwani, Rahul and Pemmaraju, Deepak B and Bhabak, Krishna P: Inflammatory-stimuli-responsive turn-on NIR fluorogenic theranostic prodrug: adjuvant delivery of diclofenac and hydrogen sulfide attenuates acute inflammatory disorders. In: Journal of Materials Chemistry B, 12, 2024, 4248--4261
2024Misra, Roopjyoti and Bhuyan, Hirak Jyoti and Dutta, Amlan and Bhabak, Krishna P: Recent Developments On Activatable Turn-On Fluorogenic Donors of Hydrogen Sulfide (H2S). In: ChemMedChem, 19, 2024, e202400251
2024Kesarwani, Rahul and Pal, Nikita and Bhabak, Krishna P: Stimuli-responsive biotin-anchored prodrug for the targeted delivery of anti-cancer agent NBDHEX with turn-on NIR fluorescence. In: Chemical Communications, 60, 2024, 3397--3400
2024Barman, Pallavi and Misra, Roopjyoti and Pal, Nikita and Sarkar, Shilpi and Bhabak, Krishna P: Synthetic Benzylic Diselenides and Disulfides: Potential Anticancer Activities via Modulation of the ROS-Dependent Akt/$\beta$-Catenin Signaling Pathway. In: ChemMedChem, 19, 2024, e202400358
2023Mahato, Sulendar K and Barman, Pallavi and Badirujjaman, Md and Bhabak, Krishna P: Cysteine-responsive prodrug of the anti-cancer drug amonafide: fluorogenic adjuvant drug delivery with hydrogen sulfide (H 2 S). In: Chemical Communications, 59, 2023, 4802--4805
2023Sufian, Abu and Badirujjaman, Md and Barman, Pallavi and Bhabak, Krishna P: Dual-Stimuli-Activatable Hybrid Prodrug for the Self-Immolative Delivery of an Anticancer Agent and Hydrogen Sulfide with Turn-On Fluorescence. In: Chemistry--A European Journal, 29, 2023, e202302197
2023Badirujjaman, Md and Pal, Nikita and Bhabak, Krishna P: Small-molecule organoselenocyanates: recent developments toward synthesis, anticancer, and antioxidant activities. In: Current Opinion in Chemical Biology, 75, 2023, 102337
2022Banerjee, Kaustav and Bhattacherjee, Debojit and Raina, Khyati and Thummer, Rajkumar P and Bhabak, Krishna Pada: Benzimidazole-based ionic and non-ionic organoselenium compounds: innovative synthetic strategies, structural characterization and preliminary anti-proliferative activities. In: New Journal of Chemistry, 46, 2022, 11910--11926
2022Sufian, Abu and Bhattacherjee, Debojit and Barman, Pallavi and Srivastava, Abhay and Thummer, Rajkumar P and Bhabak, Krishna P: Stimuli-responsive prodrug of non-steroidal anti-inflammatory drug diclofenac: self-immolative drug release with turn-on near-infrared fluorescence. In: Chemical Communications, 58, 2022, 7833--7836
2022Bhattacherjee, Debojit and Raina, Khyati and Mandal, Tapas K and Thummer, Rajkumar P and Bhabak, Krishna P: Targeting Wnt/$\beta$-catenin signaling pathway in triple-negative breast cancer by benzylic organotrisulfides: Contribution of the released hydrogen sulfide towards potent anti-cancer activity. In: Free Radical Biology and Medicine, 191, 2022, 82--96
2022Mahato, Sulendar K and Bhattacherjee, Debojit and Barman, Pallavi and Bhabak, Krishna P: Thioredoxin reductase-triggered fluorogenic donor of hydrogen sulfide: a model study with a symmetrical organopolysulfide probe with turn-on near-infrared fluorescent emission. In: Journal of Materials Chemistry B, 10, 2022, 2183--2193
2022Ravula, Rajasekhar and Bhabak, Krishna Pada and Mandal, Tapas K: User-friendly point of care test device for detection of arsenic in potable water: Prototype, design, and artifact. In: Asia-Pacific Journal of Chemical Engineering, 17, 2022, e2815
2022Ghosh, Suvankar and Bhattacherjee, Debojit and Satpati, Priyadarshi and Bhabak, Krishna Pada: Venetoclax: a promising repurposed drug against SARS-CoV-2 main protease. In: Journal of Biomolecular Structure and Dynamics, 40, 2022, 12088--12099
2021Banerjee, Kaustav and Bhattacherjee, Debojit and Mahato, Sulendar K and Sufian, Abu and Bhabak, Krishna Pada: Benzimidazole-and imidazole-fused selenazolium and selenazinium selenocyanates: ionic organoselenium compounds with efficient peroxide scavenging activities. In: Inorganic Chemistry, 60, 2021, 12984--12999
2021Sufian, Abu and Bhattacherjee, Debojit and Mishra, Tripti and Bhabak, Krishna P: Peroxide-responsive boronate ester-coupled turn-on fluorogenic probes: Direct linkers supersede self-immolative linkers for sensing peroxides. In: Dyes and Pigments, 191, 2021, 109363
2020Mahato, Sulendar K and Bhattacherjee, Debojit and Bhabak, Krishna P: The biothiol-triggered organotrisulfide-based self-immolative fluorogenic donors of hydrogen sulfide enable lysosomal trafficking. In: Chemical Communications, 56, 2020, 7769--7772
2019Malviya, Novina and Sonkar, Chanchal and Ganguly, Rakesh and Bhattacherjee, Debojit and Bhabak, Krishna Pada and Mukhopadhyay, Suman: Novel approach to generate a self-deliverable Ru (II)-based anticancer agent in the self-reacting confined gel space. In: ACS applied materials \& interfaces, 11, 2019, 47606--47618
2019Bhattacherjee, Debojit and Sufian, Abu and Mahato, Sulendar K and Begum, Samiyara and Banerjee, Kaustav and De, Sharmistha and Srivastava, Hemant Kumar and Bhabak, Krishna P: Trisulfides over disulfides: highly selective synthetic strategies, anti-proliferative activities and sustained H 2 S release profiles. In: Chemical Communications, 55, 2019, 13534--13537
2018Banerjee, Kaustav and Padmavathi, Ganesan and Bhattacherjee, Debojit and Saha, Suchismita and Kunnumakkara, Ajaikumar B and Bhabak, Krishna P: Potent anti-proliferative activities of organochalcogenocyanates towards breast cancer. In: Organic \& Biomolecular Chemistry, 16, 2018, 8769--8782
2018Mandal, Poulami and Kundu, Bidyut Kumar and Vyas, Komal and Sabu, Vidya and Helen, A and Dhankhar, Sandeep Singh and Nagaraja, CM and Bhattacherjee, Debojit and Bhabak, Krishna Pada and Mukhopadhyay, Suman: Ruthenium (ii) arene NSAID complexes: inhibition of cyclooxygenase and antiproliferative activity against cancer cell lines. In: Dalton transactions, 47, 2018, 517--527
2017Saha, Manideepa and Vyas, Komal M and Martins, Lu{\'\i}sa MDRS and Martins, Nuno MR and Pombeiro, Armando JL and Mobin, Shaikh M and Bhattacherjee, D and Bhabak, Krishna P and Mukhopadhyay, Suman: Copper (II) tetrazolato complexes: Role in oxidation catalysis and protein binding. In: Polyhedron, 132, 2017, 53--63
2017Bhattacherjee, Debojit and Basu, Chitra and Bhardwaj, Queen and Mal, Sourav and Sahu, Subhajit and Sur, Runa and Bhabak, Krishna P: Design, synthesis and anti-cancer activities of benzyl analogues of garlic-derived diallyl disulfide (DADS) and the corresponding diselenides. In: ChemistrySelect, 2, 2017, 7399--7406
2016Bhattacherjee, Debojit and Bhabak, Krishna Pada: Atom based 3D-QSAR studies on 2, 4-dioxopyrimidine-1-carboxamide analogs: Validation of experimental inhibitory potencies towards acid ceramidase. In: European Journal of Pharmaceutical Sciences, 83, 2016, 8--18
2016Bhabak, Krishna P and Bhowmick, Debasish: Synthetic strategies of gold (I)-selenolates from ortho-substituted diaryl diselenides via selenol and selenenyl sulfide intermediates. In: Inorganica Chimica Acta, 450, 2016, 337--345
2013Bhabak, Krishna P and Hauser, Anett and Redmer, Susanne and Banhart, Sebastian and Heuer, Dagmar and Arenz, Christoph: Cover Picture: Development of a Novel FRET Probe for the Real-Time Determination of Ceramidase Activity (ChemBioChem 9/2013). In: ChemBioChem, 14, 2013, 1017--1017
2013Bhabak, Krishna P and Hauser, Anett and Redmer, Susanne and Banhart, Sebastian and Heuer, Dagmar and Arenz, Christoph: Development of a novel FRET probe for the real-time determination of ceramidase activity. In: ChemBioChem, 14, 2013, 1049--1052
2013Bhabak, Krishna P and Kleuser, Burkhard and Huwiler, Andrea and Arenz, Christoph: Effective inhibition of acid and neutral ceramidases by novel B-13 and LCL-464 analogues. In: Bioorganic \& Medicinal Chemistry, 21, 2013, 874--882
2013Bhabak, Krishna P and Arenz, Christoph: Novel drugs targeting sphingolipid metabolism. In: Sphingolipids: Basic Science and Drug Development, 2013, 187--196
2013Bhabak, Krishna Pada and Bhowmick, Debasish and Mugesh, Govindasamy: Synthetic glutathione peroxidase mimics: Effect of nucleophilicity of the aryl thiol cofactor on the antioxidant activity. In: Indian J. Chem, 52, 2013, 1019--1025
2012Bhabak, Krishna P and Arenz, Christoph: Novel amide-and sulfonamide-based aromatic ethanolamines: effects of various substituents on the inhibition of acid and neutral ceramidases. In: Bioorganic \& medicinal chemistry, 20, 2012, 6162--6170
2012Bhabak, Krishna P and Bhowmick, Debasish: Synthesis and structural characterization of some trisulfide analoges of thiouracil-based antithyroid drugs. In: Journal of Molecular Structure, 1022, 2012, 16--24
2011Bhabak, Krishna P and Bhuyan, Bhaskar J and Mugesh, Govindasamy: Bioinorganic and medicinal chemistry: aspects of gold (I)-protein complexes. In: Dalton Transactions, 40, 2011, 2099--2111
2011Bhabak, Krishna P and Mugesh, Govindasamy: Gold (I)-selenolate complexes: Synthesis, characterization and ligand exchange reactions. In: Journal of Chemical Sciences, 123, 2011, 783--789
2011Bhabak, Krishna P and Satheeshkumar, Kandhan and Jayavelu, Subramaniam and Mugesh, Govindasamy: Inhibition of peroxynitrite-and peroxidase-mediated proteintyrosine nitration by imidazole-based thiourea and selenourea derivatives. In: Organic \& Biomolecular Chemistry, 9, 2011, 7343--7350
2011Roy, Gouriprasanna and Bhabak, Krishna P and Mugesh, Govindasamy: Interactions of antithyroid drugs and their analogues with halogens and their biological implications. In: Crystal growth \& design, 11, 2011, 2279--2286
2011Bhabak, Krishna P and Vernekar, Amit A and Jakka, Surendar R and Roy, Gouriprasanna and Mugesh, Govindasamy: Mechanistic investigations on the efficient catalytic decomposition of peroxynitrite by ebselen analogues. In: Organic \& Biomolecular Chemistry, 9, 2011, 5193--5200
2011Bhabak, Krishna P and Mugesh, Govindasamy: Synthesis and characterization of some gold (I)-thiolate complexes having N-methylimidazole moiety. In: Indian Journal of Chemistry-Section A: Inorganic, Physical, Theoretical and Analytical Chemistry, 50, 2011, 1303--1307
2011Bhabak, Krishna P and Mugesh, Govindasamy: Synthetic mimics of selenoproteins. Selenoproteins and Mimics. Springer Berlin Heidelberg Berlin, Heidelberg, 2011. 207--221
2010Bhabak, Krishna P and Mugesh, Govindasamy: Antithyroid Drugs and their Analogues Protect Against Peroxynitrite-Mediated Protein Tyrosine Nitration—A Mechanistic Study. In: Chemistry--A European Journal, 16, 2010, 1175--1185
2010Bhabak, Krishna P and Mugesh, Govindasamy: Cover Picture: Antithyroid Drugs and their Analogues Protect Against Peroxynitrite-Mediated Protein Tyrosine Nitration—A Mechanistic Study (Chem. Eur. J. 4/2010). In: Chemistry--A European Journal, 16, 2010, 1087--1087
2010Bhabak, Krishna P and Mugesh, Govindasamy: Functional mimics of glutathione peroxidase: bioinspired synthetic antioxidants. In: Accounts of chemical research, 43, 2010, 1408--1419
2010Bhabak, Krishna P and Mugesh, Govindasamy: Inhibition of peroxidase-catalyzed protein tyrosine nitration by antithyroid drugs and their analogues. In: Inorganica Chimica Acta, 363, 2010, 2812--2818
2009Bhabak, Krishna P and Mugesh, Govindasamy: A synthetic model for the inhibition of glutathione peroxidase by antiarthritic gold compounds. In: Inorganic chemistry, 48, 2009, 2449--2455
2009Bhabak, Krishna P and Mugesh, Govindasamy: Amide-based glutathione peroxidase mimics: effect of secondary and tertiary amide substituents on antioxidant activity. In: Chemistry--An Asian Journal, 4, 2009, 974--983
2009Bhabak, Krishna P and Mugesh, Govindasamy: Synthesis and Structure--Activity Correlation Studies of Secondary-and Tertiary-Amine-Based Glutathione Peroxidase Mimics. In: Chemistry--A European Journal, 15, 2009, 9846--9854
2008Bhabak, Krishna P and Mugesh, Govindasamy: A simple and efficient strategy to enhance the antioxidant activities of amino-substituted glutathione peroxidase mimics. In: Chemistry--A European Journal, 14, 2008, 8640--8651
2007Bhabak, Krishna P and Mugesh, Govindasamy: Synthesis, characterization, and antioxidant activity of some ebselen analogues. In: Chemistry--A European Journal, 13, 2007, 4594--4601